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AC1115

Chemical Structure : AC1115

CAS No.: 890648-80-3

AC1115 (AC 1115)

货号: PC-21710Not For Human Use, Lab Use Only.

AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.
    AC1115 displays potent inhibition of both wild-type Mpro from the WA-1 strain and Omicron Mpro with IC50 of 2.44 and 14.27 nM, respectively.
    AC1115 also displays potent reversible inhibition of human CTSL activity with IC50 of 0.06 nM, >40-fold selective over other members of the human cysteine cathepsin family.
    AC1115 showsno significant inhibition against a panel of 56 human and virus proteases.
    AC1115 displays antiviral activity against SARS-CoV-2 VOCs, including WA-1, Alpha, Beta, Delta, Lambda, and Gamma variants with EC50 of 0.28-4.26 μM.

    物理化学性质&存储条件

    分子量 412.49
    分子式 C22H28N4O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide

    参考文献

    1. Long Mao, et al. Med. 2024 Jan 12;5(1):42-61.e23.

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