AC1115 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : AC1115

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AC1115 (AC 1115)

货号: PC-21710Not For Human Use, Lab Use Only.

AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.

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生物&药学活性

AC1115 is a potent, selective, next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, AC1115 is the active form of Olgotrelvir.
AC1115 displays potent inhibition of both wild-type Mpro from the WA-1 strain and Omicron Mpro with IC50 of 2.44 and 14.27 nM, respectively.
AC1115 also displays potent reversible inhibition of human CTSL activity with IC50 of 0.06 nM, >40-fold selective over other members of the human cysteine cathepsin family.
AC1115 showsno significant inhibition against a panel of 56 human and virus proteases.
AC1115 displays antiviral activity against SARS-CoV-2 VOCs, including WA-1, Alpha, Beta, Delta, Lambda, and Gamma variants with EC50 of 0.28-4.26 μM.

物理化学性质&存储条件

分子量	412.49
分子式	C22H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide

参考文献

1. Long Mao, et al. Med. 2024 Jan 12;5(1):42-61.e23.

AC1115 (AC 1115)

生物&药学活性

物理化学性质&存储条件

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AC1115 (AC 1115)

生物&药学活性

物理化学性质&存储条件

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