(R)-BA-1049 (NRL-1049) | ROCK2 inhibitor | Probechem Biochemicals

Chemical Structure : (R)-BA-1049

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(R)-BA-1049 (BA-1049 R-form, (R)-BA1049, NRL-1049)

货号: PC-20084Not For Human Use, Lab Use Only.

(R)-BA-1049 (NRL-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.

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生物&药学活性

(R)-BA-1049 (NRL-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
Neither BA-1049 nor the metabolite inhibits PKA or PKC at physiological ATP concentrations.
BA-1049 is a promising drug candidate to reduce lesion growth and hemorrhage in both CCM1 and CCM3 models of cavernous angioma (CA).

物理化学性质&存储条件

分子量	319.42
分子式	C16H21N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine

参考文献

1. Lisa McKerracher, et al. Transl Stroke Res. 2020 Jun;11(3):365-376.

2. Patent US20170313680A1.

(R)-BA-1049 (BA-1049 R-form, (R)-BA1049, NRL-1049)

生物&药学活性

物理化学性质&存储条件

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(R)-BA-1049 (BA-1049 R-form, (R)-BA1049, NRL-1049)

生物&药学活性

物理化学性质&存储条件

参考文献

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