(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist (Kd=2.2 nM) with no μ-opioid antagonist effects.
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist (Kd=2.2 nM) with no μ-opioid antagonist effects.
(-)-U-50488 hydrochloride shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.
