YD-277 |CAS: 2468202-78-8 Probechem Biochemicals

Chemical Structure : YD-277

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YD-277 (YD 277;YD277)

货号: PC-60426Not For Human Use, Lab Use Only.

YD-277 is a novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.

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生物&药学活性

YD-277 is a novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.
YD-277 decreases cancer cell viability in a KLF5-independent manner, induces G1 cell cycle arrest and promotes apoptosis through activating IRE1α in MDA-MB-231 and MDA-MB-468 cell.
YD-277 significantly inhibits the growth of MDA-MB-231 tumor xenografts in nude mice.

物理化学性质&存储条件

分子量	435.949
分子式	C22H30ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (E)-4-(2-(3-(3-chlorophenyl)acrylamido)-N-methylacetamido)piperidine-1-carboxylate

参考文献

1. Chen Z, et al. Theranostics. 2017 Jun 11;7(8):2339-2349.

YD-277 (YD 277;YD277)

生物&药学活性

物理化学性质&存储条件

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YD-277 (YD 277;YD277)

生物&药学活性

物理化学性质&存储条件

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