XR5118 | PAI-1 inhibitor Probechem Biochemicals

Chemical Structure : XR 5118

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XR 5118 (XR5118)

货号: PC-62457Not For Human Use, Lab Use Only.

XR5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion.

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生物&药学活性

XR5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion.
XR5118 is the first nonpeptide compound with significant anti-PAI-1 activity in vivo.

物理化学性质&存储条件

分子量	435.985
分子式	C20H22ClN3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5-Piperazinedione, 3-[[5-[[2-(dimethylamino)ethyl]thio]-2-thienyl]methylene]-6-(phenylmethylene)-, monohydrochloride, (Z,Z)-

参考文献

1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21.

2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32.

3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92.

XR 5118 (XR5118)

生物&药学活性

物理化学性质&存储条件

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XR 5118 (XR5118)

生物&药学活性

物理化学性质&存储条件

参考文献

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