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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-WIN-18446
WIN-18446

Chemical Structure : WIN-18446

CAS No.: 1477-57-2

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WIN-18446 (WIN18446;WIN 18446)

货号: PC-60168Not For Human Use, Lab Use Only.

WIN-18446 is a potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.

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50 mg ￥780 In stock
100 mg ￥1280 In stock
200 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WIN-18446 is a potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.
WIN-18446 potently inhibits spermatogenesis and causes infertility in vivo by inhibiting retinoic acid synthesis.

物理化学性质&存储条件

分子量 366.11
分子式 C12H20Cl4N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)

参考文献

1. Amory JK, et al. J Androl. 2011 Jan-Feb;32(1):111-9.

2. Paik J, et al. J Biol Chem. 2014 May 23;289(21):15104-17.

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