Tegatrabetan |CAS:1227637-23-1 Probechem Biochemicals

Chemical Structure : Tegatrabetan

CAS No.: 1227637-23-1

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Tegatrabetan (BC-2059;BC2059;Tegavivint)

货号: PC-61288Not For Human Use, Lab Use Only.

Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.
BC-2059 reduces transcriptional activity of TCF4 and expression of its target genes, cyclin D1, c-MYC and survivin.
BC-2059 treatment dose-dependently induced apoptosis of cultured and primary AML BPCs.
BC-2059 significantly improves the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs.

物理化学性质&存储条件

分子量	588.74
分子式	C28H36N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-

参考文献

1. Fiskus W, et al. Leukemia. 2015 Jun;29(6):1267-78.

2. Savvidou I, et al. Mol Cancer Ther. 2017 Sep;16(9):1765-1778.

Tegatrabetan (BC-2059;BC2059;Tegavivint)

生物&药学活性

物理化学性质&存储条件

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Tegatrabetan (BC-2059;BC2059;Tegavivint)

生物&药学活性

物理化学性质&存储条件

参考文献

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