Sulfatinib |CAS:1308672-74-3 Probechem Biochemicals

Chemical Structure : Sulfatinib

CAS No.: 1308672-74-3

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Sulfatinib (HMPL-012;Surufatinib;HMPL012)

货号: PC-42960Not For Human Use, Lab Use Only.

Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.

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生物&药学活性

Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.
Sulfatinib (HMPL-012) also potently inhibits TrkB and FLT-3 with IC50 of 41 and 67 nM, shows little to no activity against other 278 other kinases (IC50>150 nM).
Sulfatinib (HMPL-012) targets tumor angiogenesis and immune modulation, exhibits an acceptable safety profile and encouraging antitumor activity in clinical investigations.

物理化学性质&存储条件

分子量	480.5825
分子式	C24H28N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzenemethanesulfonamide, N-[2-(dimethylamino)ethyl]-3-[[4-[(2-methyl-1H-indol-5-yl)oxy]-2-pyrimidinyl]amino]-

参考文献

1. Xu JM, et al. Oncotarget. 2017 Jun 27;8(26):42076-42086.

Sulfatinib (HMPL-012;Surufatinib;HMPL012)

生物&药学活性

物理化学性质&存储条件

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Sulfatinib (HMPL-012;Surufatinib;HMPL012)

生物&药学活性

物理化学性质&存储条件

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