Sotorasib (AMG-510) | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : Sotorasib (AMG-510)

CAS No.: 2296729-00-3

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Sotorasib (AMG-510) (AMG510)

货号: PC-22982Not For Human Use, Lab Use Only.

Sotorasib (AMG510) racemate s a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Sotorasib (AMG510) racemate s a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM.
AMG510 showed great promise in the treatment of KRAS p.G12C-mutant tumors both pre-clinically and clinically.
Treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of chemotherapy and targeted agents.
In immune-competent mice, treatment with AMG 510 resulted in a pro-inflammatory tumour microenvironment and produced durable cures alone as well as in combination with immune-checkpoint inhibitors.

物理化学性质&存储条件

分子量	560.61
分子式	C30H30F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one

参考文献

1. Lanman BA, et al. J Med Chem. 2020 Jan 9;63(1):52-65.

2. Canon J, et al. Nature. 2019 Nov;575(7781):217-223.

3. Ryan MB, et al. Clin Cancer Res. 2020 Apr 1;26(7):1633-1643.

4. McCormick F. Cancer Cell. 2020 Jan 13;37(1):3-4.

Sotorasib (AMG-510) (AMG510)

生物&药学活性

物理化学性质&存储条件

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Sotorasib (AMG-510) (AMG510)

生物&药学活性

物理化学性质&存储条件

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