SN-32976 |CAS:1246202-11-8 Probechem Biochemicals

Chemical Structure : SN-32976

CAS No.: 1246202-11-8

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SN-32976 (SN 32976;SN32976)

货号: PC-60392Not For Human Use, Lab Use Only.

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.

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10 mg	￥3980	In stock
25 mg	￥5880	In stock
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生物&药学活性

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.
SN-32976 displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases.
SN-32976 inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.

物理化学性质&存储条件

分子量	581.64
分子式	C24H33F2N9O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)sulfonyl)-N,N-dimethylethan-1-amine

参考文献

1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730.

SN-32976 (SN 32976;SN32976)

生物&药学活性

物理化学性质&存储条件

参考文献

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SN-32976 (SN 32976;SN32976)

生物&药学活性

物理化学性质&存储条件

参考文献

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