SHP-099 |CAS:1801747-42-1 Probechem Biochemicals

Chemical Structure : SHP-099

CAS No.: 1801747-42-1

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SHP-099 (SHP099)

货号: PC-42128Not For Human Use, Lab Use Only.

SHP-099 (SHP099) is a potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

SHP-099 (SHP099) is a potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM.
SHP-099 exhibits excellent phosphatase selectivity profiling over a panel of 21 human phosphatases (including SHP1) and a panel of 66 serine-threonine and tyrosine kinase.
SHP-099 inhibits p-ERK with an IC50 of ~0.25 uM in SHP2- dependent MDA-MB-468 and KYSE520 cells, suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro.
SHP-099 is efficacious in mouse tumour xenograft models.

物理化学性质&存储条件

分子量	352.2616
分子式	C16H19Cl2N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.4 mg/mL (Need ultrasonic)
Chemical Name/SMILES	2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-

参考文献

1. Garcia Fortanet J, et al. J Med Chem. 2016 Sep 8;59(17):7773-82.

2. Chen YN, et al. Nature. 2016 Jul 7;535(7610):148-52.

3. Flemming A. Nat Rev Drug Discov. 2016 Jul 29;15(8):530-1.

SHP-099 (SHP099)

生物&药学活性

物理化学性质&存储条件

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SHP-099 (SHP099)

生物&药学活性

物理化学性质&存储条件

参考文献

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