SCH-527123 |CAS:473727-83-2 Probechem Biochemicals

Chemical Structure : SCH-527123

CAS No.: 473727-83-2

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SCH-527123 (SCH527123;Navarixin;SCH 527123;MK-7123)

货号: PC-42443Not For Human Use, Lab Use Only.

SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.

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10 mg	￥1480	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
SCH-527123 potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM.
SCH-527123 inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.

物理化学性质&存储条件

分子量	397.4244
分子式	C21H23N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-

参考文献

1. Chapman RW, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):486-93.

2. Dwyer MP, et al. J Med Chem. 2006 Dec 28;49(26):7603-6.

3. Gonsiorek W, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):477-85.

4. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.

SCH-527123 (SCH527123;Navarixin;SCH 527123;MK-7123)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

SCH-527123 (SCH527123;Navarixin;SCH 527123;MK-7123)

生物&药学活性

物理化学性质&存储条件

参考文献

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