SBP7455 | ULK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : SBP7455

CAS No.: 1884222-74-5

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SBP7455 (SBP-7455, SBP 7455)

货号: PC-21693Not For Human Use, Lab Use Only.

SBP-7455 is a potent, selective and orally active ULK1/2 inhibitor with IC50 of 13 nM (ULK1) and 476 nM (ULK2) in ADP-Glo assays, selectively blocks autophagic flux in TNBC cell lines.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

SBP-7455 is a potent, selective and orally active ULK1/2 inhibitor with IC50 of 13 nM (ULK1) and 476 nM (ULK2) in ADP-Glo assays, selectively blocks autophagic flux in TNBC cell lines.
SBP-7455 blocks phosphorylation of downstream autophagy target proteins Beclin1 and VPS34.
SBP-7455 is an efficacious tool that can be used to modulate autophagy in vivo.
SBP-7455 is cytotoxic as single agents against TNBC cells with IC50 of 0.3 uM for MDA-MB-468 cells, which is more potent than SBI-0206965.
SBP-7455 promotes apoptosis in TNBC cells under nutrient-deprived conditions.
SBP-7455 reduces autophagic flux and exhibits synergistic cytotoxicity with the PARP inhibitor olaparib against MDA-MB-468 cells, reverses olaparib-induced autophagic flux.

物理化学性质&存储条件

分子量	354.33
分子式	C16H17F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-Cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

参考文献

1. Huiyu Ren, et al. J Med Chem. 2020 Dec 10;63(23):14609-14625.

SBP7455 (SBP-7455, SBP 7455)

生物&药学活性

物理化学性质&存储条件

参考文献

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SBP7455 (SBP-7455, SBP 7455)

生物&药学活性

物理化学性质&存储条件

参考文献

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