SBC 115076 |CAS:489415-96-5 Probechem Biochemicals

Chemical Structure : SBC 115076

CAS No.: 489415-96-5

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SBC 115076 (SBC115076)

货号: PC-63171Not For Human Use, Lab Use Only.

SBC 115076 is a PCSK9 modulator that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

SBC 115076 is a PCSK9 modulator that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
SBC 115076 effectively lowers cholesterol levels in high fat diet mice.

物理化学性质&存储条件

分子量	527.621
分子式	C31H33N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one

参考文献

1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

SBC 115076 (SBC115076)

生物&药学活性

物理化学性质&存储条件

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SBC 115076 (SBC115076)

生物&药学活性

物理化学性质&存储条件

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