SB772077B |CAS:785774-34-7 Probechem Biochemicals

Chemical Structure : SB772077B

CAS No.: 785774-34-7

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SB772077B (SB-772077B;SB77;SB-772077-B)

货号: PC-35737Not For Human Use, Lab Use Only.

SB772077B (SB-772077B, SB77, SB-772077-B) is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 5.6 nM and 6.0 nM for ROCK1 and ROCK2, respectively.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SB772077B (SB-772077B, SB77, SB-772077-B) is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 5.6 nM and 6.0 nM for ROCK1 and ROCK2, respectively.
SB772077B blocks the generation of inflammatory cytokines, such as IL-6 and TNF-alpha.
SB772077B induces vasorelaxation in preconstricted rat aorta with IC50 of 39 nM; produces a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量	342.363
分子式	C15H18N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

参考文献

1. Doe C, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.

2. Ashwinbalaji S, et al. Sci Rep. 2018 Oct 19;8(1):15472.

SB772077B (SB-772077B;SB77;SB-772077-B)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB772077B (SB-772077B;SB77;SB-772077-B)

生物&药学活性

物理化学性质&存储条件

参考文献

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