SB-225002 |CAS:182498-32-4 Probechem Biochemicals

Chemical Structure : SB-225002

CAS No.: 182498-32-4

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SB-225002 (SB225002)

货号: PC-45057Not For Human Use, Lab Use Only.

SB-225002 (SB225002) is a potent, selective, non-peptide CXCR2 antagonist with IC50 of 22 nM.

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25 mg	￥1980	In stock
100 mg	￥4980	In stock
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生物&药学活性

SB-225002 (SB225002) is a potent, selective, non-peptide CXCR2 antagonist with IC50 of 22 nM.
SB-225002 displays >150-fold selectivity over CXCR1.
SB-225002 potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro.
SB-225002 selectively blocks IL-8-induced neutrophil margination in rabbits.

物理化学性质&存储条件

分子量	352.1402
分子式	C13H10BrN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-

参考文献

1. White JR, et al. J Biol Chem. 1998 Apr 24;273(17):10095-8.

2. Auten RL, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.

3. Manjavachi MN, et al. Eur J Pain. 2010 Jan;14(1):23-31.

SB-225002 (SB225002)

生物&药学活性

物理化学性质&存储条件

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SB-225002 (SB225002)

生物&药学活性

物理化学性质&存储条件

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