RPL-554 | PDE3/PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : RPL-554

CAS No.: 1884461-72-6

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RPL-554 (Ensifentrine, LS-193855, RPL554)

货号: PC-60220Not For Human Use, Lab Use Only.

RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
RPL-554 inhibits LPS-induced TNFα release from human monocytes with IC50 of 0.52 uM, and proliferation of human mononuclear cells to phytohemagglutinin (IC50=0.46 uM).
RPL-554 significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs (10mg/kg).

物理化学性质&存储条件

分子量	477.554
分子式	C26H31N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea

参考文献

1. Boswell-Smith V, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8.

2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.

3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.

RPL-554 (Ensifentrine, LS-193855, RPL554)

生物&药学活性

物理化学性质&存储条件

参考文献

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RPL-554 (Ensifentrine, LS-193855, RPL554)

生物&药学活性

物理化学性质&存储条件

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