Pyrotinib maleate |CAS:1397922-61-0 Probechem Biochemicals

Chemical Structure : Pyrotinib maleate

CAS No.: 1397922-61-0

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Pyrotinib maleate (SHR-1258 maleate;SHR1258 maleate)

货号: PC-70083Not For Human Use, Lab Use Only.

Pyrotinib maleate (SHR-1258 maleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively.

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生物&药学活性

Pyrotinib maleate (SHR-1258 maleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively; displays high selectivity in a panel of different kinases such as KDR, c-Kit, PDGFRβ, c-Src and c-Met (c-Src with an IC50 of 790 nM, and others >3,000 nM); exhibits robust anti-tumor effects on HER2-overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human.

Breast Cancer

Phase 3 Clinical

物理化学性质&存储条件

分子量	699.161
分子式	C36H35ClN6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide dimaleate

参考文献

1. Li X, et al. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.

Pyrotinib maleate (SHR-1258 maleate;SHR1258 maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pyrotinib maleate (SHR-1258 maleate;SHR1258 maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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