PK-7088 |CAS:1446352-67-5 Probechem Biochemicals

Chemical Structure : PK-7088

CAS No.: 1446352-67-5

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PK-7088 (PK7088)

货号: PC-62081Not For Human Use, Lab Use Only.

PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria..

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10 mg	￥2180	In stock
25 mg	￥3880	In stock
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生物&药学活性

PK-7088 (PK7088) is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.

物理化学性质&存储条件

分子量	223.279
分子式	C14H13N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole

参考文献

1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.

2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.

3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.

PK-7088 (PK7088)

生物&药学活性

物理化学性质&存储条件

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PK-7088 (PK7088)

生物&药学活性

物理化学性质&存储条件

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