PIKfyve inhibitor 17

Chemical Structure : PIKfyve inhibitor 17

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货号: PC-49344Not For Human Use, Lab Use Only.

PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).
PIKfyve inhibitor 17 displays efficacious inhibition of viral replication in the MHV-nLuc assay with IC50 of 23.5 nM.
PIKfyve inhibitor 17 potently inhibits SARS-CoV-2 replication with IC50 of 19.5 nM in a SARS-CoV-2-nLuc assay in human epithelial A549-ACE2 cells, outperformed remdesivir.
PIKfyve inhibitor 17 reduces uptake of His6-SARS-CoV-2 spike protein by HEK293T-ACE2 cells, inhibits uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein and impacts lysosomal homeostasis.s

物理化学性质&存储条件

分子量	331.423
分子式	C20H21N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-(3-(Dimethylamino)prop-1-yn-1-yl)-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine

参考文献

1. David H. et al. Journal of Medicinal Chemistry 2022