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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-PF-04971729
PF-04971729

Chemical Structure : PF-04971729

CAS No.: 1210344-57-2

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PF-04971729 (Ertugliflozin, MK-8835, PF-4971729)

货号: PC-44436Not For Human Use, Lab Use Only.

Ertugliflozin (PF-04971729) is a potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ertugliflozin (PF-04971729) is a potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.
Ertugliflozin shows >2000-fold selectivity over hSGLT1.
Ertugliflozin demonstrates robust urinary glucose excretion in rats and an excellent preclinical safety profile.

物理化学性质&存储条件

分子量 436.8827
分子式 C22H25ClO7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-

参考文献

1. Mascitti V, et al. J Med Chem. 2011 Apr 28;54(8):2952-60.

2. Kalgutkar AS, et al. Drug Metab Dispos. 2011 Sep;39(9):1609-19.

3. Miao Z, et al. Drug Metab Dispos. 2013 Feb;41(2):445-56.

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