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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-PCI-24781
PCI-24781

Chemical Structure : PCI-24781

CAS No.: 783355-60-2

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PCI-24781 (CRA 024781;CRA 24781;PCI 24781;Abexinostat)

货号: PC-42767Not For Human Use, Lab Use Only.

PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM.
PCI-24781 also inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range.
PCI-24781 causes the accumulation of acetylated histone and acetylated tubulin in tumor cell lines.
PCI-24781 decreases RAD51 expression and inhibits homologous recombination.

物理化学性质&存储条件

分子量 397.4244
分子式 C21H23N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-

参考文献

1. Buggy JJ, et al. Mol Cancer Ther. 2006 May;5(5):1309-17.

2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.

3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.

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