PARP inhibitor PJ-34 | PARP inhibitor | Probechem Biochemicals

Chemical Structure : PARP inhibitor PJ-34

CAS No.: 344458-19-1

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PARP inhibitor PJ-34 (PJ34)

货号: PC-21820Not For Human Use, Lab Use Only.

PJ34 is a potent specific inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.

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25 mg	￥1880	In stock
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生物&药学活性

PJ34 is a potent specific inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
PJ34 significantly decreased myocardial PARP activation but not nitrotyrosine formation, and improved both cardiac dysfunction and vascular relaxation.
PJ34 prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.

物理化学性质&存储条件

分子量	295.34
分子式	C17H17N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide

参考文献

1. Haddad M, et al. Br J Pharmacol. 2006 Sep;149(1):23-30.

2. Abdelkarim GE, et al. Int J Mol Med. 2001 Mar;7(3):255-60.

3. Iványi Z, et al. Shock. 2003 May;19(5):415-21.

4. Pacher P, et al. J Pharmacol Exp Ther. 2002 Mar;300(3):862-7.

PARP inhibitor PJ-34 (PJ34)

生物&药学活性

物理化学性质&存储条件

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PARP inhibitor PJ-34 (PJ34)

生物&药学活性

物理化学性质&存储条件

参考文献

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