P-50429 |CAS:1247825-37-1 Probechem Biochemicals

Chemical Structure : P-50429

CAS No.: 1247825-37-1

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P-50429 (P50429;P 50429)

货号: PC-43555Not For Human Use, Lab Use Only.

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs.
P-50429 exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM).
P-50429 destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.

物理化学性质&存储条件

分子量	484.3992
分子式	C18H11Cl2N3O3S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-

参考文献

1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.

2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.

P-50429 (P50429;P 50429)

生物&药学活性

物理化学性质&存储条件

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P-50429 (P50429;P 50429)

生物&药学活性

物理化学性质&存储条件

参考文献

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