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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-Nx-1607
Nx-1607

Chemical Structure : Nx-1607

CAS No.:

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Nx-1607 (Nx1607, NX-1607)

货号: PC-21554Not For Human Use, Lab Use Only.

Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
    Nx-1607 binds to the TKBD-LHR unit of Cbl-b, locking the protein in an inactive conformation.
    Nx-1607 inhibits the interaction between the N-terminal E3 ligase fragment (TKBD-LHR-RING) of Cbl-b and UbcH5B-Ub (E2-Ub) complex in the presence of the Src kinase substrate.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Serah W Kimani, et al. Commun Biol. 2023 Dec 16;6(1):1272.

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