Buparlisib (NVP-BKM120) | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : NVP-BKM120

CAS No.: 944396-07-0

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NVP-BKM120 (BKM-120, Buparlisib)

货号: PC-45950Not For Human Use, Lab Use Only.

NVP-BKM120 (BKM-120, Buparlisib) is a potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.

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50 mg	￥1580	In stock
100 mg	￥2480	In stock
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生物&药学活性

NVP-BKM120 (BKM-120, Buparlisib) is a potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
NVP-BKM120 (BKM-120, Buparlisib) much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ and several other kinases.
NVP-BKM120 (BKM-120, Buparlisib) prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.

物理化学性质&存储条件

分子量	410.3936
分子式	C18H21F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-

参考文献

1. Maira SM, et al. Mol Cancer Ther. 2012 Feb;11(2):317-28.

2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.

3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.

NVP-BKM120 (BKM-120, Buparlisib)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVP-BKM120 (BKM-120, Buparlisib)

生物&药学活性

物理化学性质&存储条件

参考文献

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