Chemical Structure : MC-1568
CAS No.: 852475-26-4
货号: PC-45089Not For Human Use, Lab Use Only.
MC1568 is a potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.
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MC1568 is a potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.
MC1568 displays 176-fold selectivity over HD1-B.
MC1568 increases the accumulation of acetylated H3 and H4 histones in MCF-7 cells at 20 uM.
MC1568 promotes neurite growth and arbourisation and protects neurite arbours against neurotoxic insult.
分子量 | 314.311 | |
分子式 | C17H15FN2O3 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
DMSO: 18.5 mg/mL |
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Chemical Name/SMILES |
2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)- |
1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Collins LM, et al. Mol Neurobiol. 2015;51(3):1432-42.
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