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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-MC-1568
MC-1568

Chemical Structure : MC-1568

CAS No.: 852475-26-4

MC-1568 (MC1568)

货号: PC-45089Not For Human Use, Lab Use Only.

MC1568 is a potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MC1568 is a potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.
MC1568 displays 176-fold selectivity over HD1-B.
MC1568 increases the accumulation of acetylated H3 and H4 histones in MCF-7 cells at 20 uM.
MC1568 promotes neurite growth and arbourisation and protects neurite arbours against neurotoxic insult.

物理化学性质&存储条件

分子量 314.311
分子式 C17H15FN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 18.5 mg/mL

Chemical Name/SMILES

2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-

参考文献

1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.

2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.

3. Collins LM, et al. Mol Neurobiol. 2015;51(3):1432-42.

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