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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-LY-2584702 tosylate
LY-2584702 tosylate

Chemical Structure : LY-2584702 tosylate

CAS No.: 1082949-68-5

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LY-2584702 tosylate (LY-2779964, LY2584702, LY2779964)

货号: PC-43059Not For Human Use, Lab Use Only.

LY-2779964 (LY2584702 tosylate) is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1080 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY-2779964 (LY2584702 tosylate) is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
LY2584702 tosylate blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2.
LY2584702 tosylate inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM.
LY2584702 tosylate demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

物理化学性质&存储条件

分子量 617.6177
分子式 C28H27F4N7O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10.25 mg/mL
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-, 4-methylbenzenesulfonate (1:1)

参考文献

1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.

2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.

3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.

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