KP-1339 |CAS:197723-00-5 Probechem Biochemicals

Chemical Structure : KP-1339

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KP-1339 (IT-139;NKP-1339)

货号: PC-60227Not For Human Use, Lab Use Only.

A promising ruthenium anticancer compound that blocks angiogenesis, endothelial cell proliferation and migration stimulated by VEGF or NO donor agent.

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生物&药学活性

A promising ruthenium anticancer compound that blocks angiogenesis, endothelial cell proliferation and migration stimulated by VEGF or NO donor agent; potentiates the anticancer activity of sorafenib in vitro and in vivo; overcomes GRP78-mediated chemoresistance, restores sensitivity to cytotoxic drugs in drug-resistant PDAC cells in vitro and in vivo.

物理化学性质&存储条件

分子量	502.138
分子式	C14H12Cl4N4NaRu
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-indazole;tetrachlororuthenium(1-) sodium salt

参考文献

1. Heffeter P, et al. Eur J Cancer. 2013 Oct;49(15):3366-75.

2. Gifford JB, et al. Mol Cancer Ther. 2016 May;15(5):1043-52.

3. Morbidelli L, et al. Br J Cancer. 2003 May 6;88(9):1484-91.

KP-1339 (IT-139;NKP-1339)

生物&药学活性

物理化学性质&存储条件

参考文献

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KP-1339 (IT-139;NKP-1339)

生物&药学活性

物理化学性质&存储条件

参考文献

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