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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoacylglycerol Lipase (MAGL)-KML-29
KML-29

Chemical Structure : KML-29

CAS No.: 1380424-42-9

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KML-29 (KML29, KML 29)

货号: PC-45584Not For Human Use, Lab Use Only.

KML-29 is a potent, highly selective MAGL (monoacylglycerol lipase) inhibitor with IC50 of 15 nM.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KML-29 is a potent, highly selective MAGL (monoacylglycerol lipase) inhibitor with IC50 of 15 nM.
KML-29 shows no cross-activity with FAAH or other serine hydrolases.
KML-29 potently inhibits 2-AG hydrolysis, but does not affect AEA hydrolysis.
KML-29 reduces inflammatory and neuropathic nociceptive behaviour without occurrence of cannabimimetic side effects.

物理化学性质&存储条件

分子量 549.4164
分子式 C24H21F6NO7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

参考文献

1. Ignatowska-Jankowska BM, et al. Br J Pharmacol. 2014 Mar;171(6):1392-407.

2. Pasquarelli N, et al. Neuropharmacology. 2015 Apr;91:148-56.

3. Chang JW, et al. Chem Biol. 2012 May 25;19(5):579-88.

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