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首页-小分子抑制剂&激动剂-Others-Other Targets-IMU-838
IMU-838

Chemical Structure : IMU-838

CAS No.: 717824-30-1

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IMU-838 (Vidofludimus, 4sc-101, SC12267)

货号: PC-49175Not For Human Use, Lab Use Only.

Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells.

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25 mg ￥1980 In stock
50 mg ￥3580 In stock
100 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells.
Vidofludimus inhibits T cell proliferation with EC50 of 11.8 uM, with a similar effect on CpG ODN 2006-PTO dependent B cell proliferation.
Vidofludimus is specific for human DHODH and does not have off-target effect on kinases, is about 7.5-fold and about 64.4-fold more active on human DHODH as compared to rat DHODH and mouse DHODH, respectively.
Vidofludimus inhibits specifically IL–17F, IL–17A and IFN-g expression in PBMCs.
Vidofludimus is 2.6 times more potent in inhibiting DHO oxidation by human DHODH compared to teriflunomide (IC50=420 nM).
Vidofludimus shows inhibition of rat EAE motor signs in a rat experimental autoimmune encephalomyelitis (EAE) model.
Vidofludimus exerts a broad-spectrum activity against a selection of major human pathogenic viruses.

物理化学性质&存储条件

分子量 748.793
分子式 C40H34CaF2N2O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-ene-1-carboxylic acid

参考文献

1. Muehler A, et al. Mult Scler Relat Disord. 2020 Aug;43:102129.

2. Hahn F, et al. Viruses. 2020 Dec 5;12(12):1394.

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