IC-87201 |CAS:866927-10-8 Probechem Biochemicals

Chemical Structure : IC-87201

CAS No.: 866927-10-8

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IC-87201 (IC87201;IC 87201)

货号: PC-42163Not For Human Use, Lab Use Only.

IC-87201 (IC87201) is a small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity.

规格	价格	库存
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg	￥5880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

IC-87201 (IC87201) is a small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity.
IC-87201 dose-dependently blocks NMDA-induced increase in cGMP production in hippocampal cultures with IC50 of 2.7 uM.
IC-87201 inhibits NMDA-induced thermal hyperalgesia in mice with no effect on acute pain thresholds or motor coordination, also reverses mechanical allodynia induced by chronic constriction of the sciatic nerve.

物理化学性质&存储条件

分子量	309.1507
分子式	C13H10Cl2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-

参考文献

1. Florio SK, et al. Br J Pharmacol. 2009 Sep;158(2):494-506.

2. Doucet MV, et al. Neuropsychopharmacology. 2013 Jul;38(8):1575-84.

3. Bach A, et al. Sci Rep. 2015 Jul 16;5:12157.

IC-87201 (IC87201;IC 87201)

生物&药学活性

物理化学性质&存储条件

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IC-87201 (IC87201;IC 87201)

生物&药学活性

物理化学性质&存储条件

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