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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-HDM-201
HDM-201

Chemical Structure : HDM-201

CAS No.: 1448867-41-1

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HDM-201 (NVP-HDM 201;NVP HDM201;Siremadlin)

货号: PC-70003Not For Human Use, Lab Use Only.

HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.

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10 mg ￥2280 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
HDM-201 is a second generation p53-MDM2 inhibitor that recently entered phase I clinical trial.

物理化学性质&存储条件

分子量 555.4125
分子式 C26H24Cl2N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one

参考文献

1. Furet P, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4837-41.

2. Chapeau EA, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156.

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