GSK-6853 |CAS:1910124-24-1 Probechem Biochemicals

Chemical Structure : GSK-6853

CAS No.: 1910124-24-1

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GSK-6853 (GSK6853)

货号: PC-42090Not For Human Use, Lab Use Only.

GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥3280	In stock
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生物&药学活性

GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
GSK-6853 displays>1600-fold selectivity over others bromodomains (BRPF2/3, BRD4 BD1/BD2).
GSK-6853 displaces NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3 (IC50=20 nM) and disrupts chromatin binding in cell assays.
GSK-6853 demonstrates properties suitable for cellular and in vivo studies.

物理化学性质&存储条件

分子量	409.4815
分子式	C22H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-

参考文献

1. Bamborough P, et al. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

GSK-6853 (GSK6853)

生物&药学活性

物理化学性质&存储条件

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GSK-6853 (GSK6853)

生物&药学活性

物理化学性质&存储条件

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