GSK-2982772 |CAS:1622848-92-3 Probechem Biochemicals

Chemical Structure : GSK-2982772

CAS No.: 1622848-92-3

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GSK-2982772 (GSK2982772)

货号: PC-63388Not For Human Use, Lab Use Only.

GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM.

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5 mg	￥1380	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM.
GSK-2982772 inhibits RIP1-dependent inflammatory cytokine MIP-1β production in human whole blood with IC50 of 0.5 nM.
GSK-2982772 reduces spontaneous production of cytokines (IL-1β and IL-6) in a concentration-dependent fashion from ulcerative colitis explant tissue.
GSK-2982772 shows potential for the treatment of inflammatory diseases in vivo.

物理化学性质&存储条件

分子量	377.404
分子式	C20H19N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide

参考文献

1. Harris PA, et al. J Med Chem. 2017 Feb 23;60(4):1247-1261.

2. Weisel K, et al. Pharmacol Res Perspect. 2017 Dec;5(6).

GSK-2982772 (GSK2982772)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-2982772 (GSK2982772)

生物&药学活性

物理化学性质&存储条件

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