GSK-2033 |CAS:1221277-90-2 Probechem Biochemicals

Chemical Structure : GSK-2033

CAS No.: 1221277-90-2

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GSK-2033 (GSK2033)

货号: PC-63084Not For Human Use, Lab Use Only.

GSK-2033 (GSK2033) is the first potent, cell-active LXR antagonist with binding pIC50 of 7.0/7.5 for LXRα/LXRβ, respectively.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2780	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

GSK-2033 (GSK2033) is the first potent, cell-active LXR antagonist with binding pIC50 of 7.0/7.5 for LXRα/LXRβ, respectively.
GSK-2033 suppresses GC-induced gluconeogenic gene expression without affecting immune-responsive GR target genes.
GSK-2033 displays unexpected activity in the mouse NAFLD model.

物理化学性质&存储条件

分子量	591.66
分子式	C29H28F3NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

参考文献

1. Zuercher WJ, et al. J Med Chem. 2010 Apr 22;53(8):3412-6.

2. Griffett K, et al. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

3. Patel R, et al. Endocrinology. 2017 Apr 1;158(4):1034-1047.

GSK-2033 (GSK2033)

生物&药学活性

物理化学性质&存储条件

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GSK-2033 (GSK2033)

生物&药学活性

物理化学性质&存储条件

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