EYU688 (NITD-688) | DENV NS4B inhibitor | Probechem Biochemicals

Chemical Structure : EYU688 (NITD-688)

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EYU688 (NITD-688) (NITD688)

货号: PC-23167Not For Human Use, Lab Use Only.

EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.

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生物&药学活性

EYU688 (NITD-688) is a potent, specific pan-serotype inhibitor of dengue virus (DENV) NS4B protein, shows EC50 of 8-38 nM against all four DENV serotypes.
EYU688 (NITD-688) displays an EC50 value of 0.94 nM in PBMCs were infected with DENV-2.
EYU688 (NITD-688) shows potent activity against DENV (EC50 = 0.023 μM) in CPE assay, but not other flaviviruses or CHIKV.
EYU688 (NITD-688) directly binds to wild-type but not mutant NS4B with mutations T215A and A222V.
EYU688 (NITD-688) at 10, 30, or 100 mg/kg twice daily (BID) for 3 days or 30 mg/kg once daily (QD) for 3 days (oral gavage once daily (QD) or twice daily (BID) and was formulated in 0.5% methyl cellulose and 0.5% Tween 80 in water) reduces DENV-2 viremia during acute or delayed treatment of infected AG129 mice.

物理化学性质&存储条件

分子量	500.68
分子式	C25H32N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide

参考文献

1. Moquin SA, et al. Sci Transl Med. 2021 Feb 3;13(579):eabb2181.

EYU688 (NITD-688) (NITD688)

生物&药学活性

物理化学性质&存储条件

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EYU688 (NITD-688) (NITD688)

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