EPZ-015866 |CAS:1616391-87-7 Probechem Biochemicals

Chemical Structure : EPZ-015866

CAS No.: 1616391-87-7

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EPZ-015866 (GSK-591, GSK-3203591)

货号: PC-42097Not For Human Use, Lab Use Only.

EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
EPZ-015866 (GSK-591, GSK-3203591) shows excellent selectivity against other PMT enzymes observed with EPZ015666.
EPZ-015866 (GSK-591, GSK-3203591) inhibits the proliferation of Z-138 cells with IC50 of 62 nM.

物理化学性质&存储条件

分子量	380.4833
分子式	C22H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-

参考文献

1. Duncan KW, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.

2. Gerhart SV, et al. Sci Rep. 2018 Jun 26;8(1):9711.

EPZ-015866 (GSK-591, GSK-3203591)

生物&药学活性

物理化学性质&存储条件

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EPZ-015866 (GSK-591, GSK-3203591)

生物&药学活性

物理化学性质&存储条件

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