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首页-小分子抑制剂&激动剂-Others-Other Targets-ENPP1 inhibitor 32
ENPP1 inhibitor 32

Chemical Structure : ENPP1 inhibitor 32

CAS No.: 2298391-60-1

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ENPP1 inhibitor 32

货号: PC-38280Not For Human Use, Lab Use Only.

ENPP1 inhibitor 32 is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM.

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2 mg ￥1980 In stock
5 mg ￥3280 In stock
10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ENPP1 inhibitor 32 is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM,
ENPP1 inhibitor 32 prevents cGAMP degradation in mouse and human plasma at nanomolar concentrations (IC95=40 nM).
ENPP1 inhibitor 32 exhibits excellent physicochemical and pharmacokinetic properties, and delays tumor growth in a breast cancer mouse model.

物理化学性质&存储条件

分子量 351.343
分子式 C16H22N3O4P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO (3.5 mg/mL)
Chemical Name/SMILES

P-[2-[1-(8-Methoxy-4-quinazolinyl)-4-piperidinyl]ethyl]phosphonic acid

参考文献

1. Jacqueline A Carozza, et al. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5.

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