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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-EB‐42168
EB‐42168

Chemical Structure : EB‐42168

CAS No.: 2390475-78-0

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EB‐42168 (EB42168)

货号: PC-21888Not For Human Use, Lab Use Only.

EB‐42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EB‐42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2.

物理化学性质&存储条件

分子量 500.57
分子式 C25H28N10O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,5,7,7-Tetramethyl-N-(3-(2-morpholinopyridin-4-yl)-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

参考文献

1. Albert W Garofalo, et al. J Med Chem. 2020 Dec 10;63(23):14821-14839.

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