DS-1001b free base |CAS:1898206-17-1 Probechem Biochemicals

Chemical Structure : DS-1001b free base

CAS No.: 1898206-17-1

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DS-1001b free base (DS1001b, Safusidenib)

货号: PC-38188Not For Human Use, Lab Use Only.

DS-1001b free base (DS1001b, Safusidenib) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants.

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25 mg	￥1380	In stock
100 mg	￥3580	In stock
200 mg	￥5580	In stock
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生物&药学活性

DS-1001b free base (DS1001b, Safusidenib) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants.
DS-1001b strongly inhibited mutant IDH1, but not wild-type IDH1 or mutant IDH2 (IC50>10 uM).
DS-1001b impairs the proliferation of IDH1 mutant GBM cells and induces differentiation in a subcutaneous PDX model, but not the growth of IDH wild-type GBM.
DS-1001b permeates the BBB and inhibits tumor growth in an orthotopic PDX model.

物理化学性质&存储条件

分子量	535.777
分子式	C25H18Cl3FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylic acid

参考文献

1. Yukino Machida, et al. Mol Cancer Ther. 2020 Feb;19(2):375-383.

2. Nakagawa M, et al. Oncogene. 2019 Oct;38(42):6835-6849.

DS-1001b free base (DS1001b, Safusidenib)

生物&药学活性

物理化学性质&存储条件

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DS-1001b free base (DS1001b, Safusidenib)

生物&药学活性

物理化学性质&存储条件

参考文献

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