DEBIO 1143 |CAS:1071992-99-8 Probechem Biochemicals

Chemical Structure : DEBIO 1143

CAS No.: 1071992-99-8

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DEBIO 1143 (Xevinapant;AT-406;DEBIO1143;SM406;ARRY-334543;D1143)

货号: PC-35889Not For Human Use, Lab Use Only.

DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.

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10 mg	￥1380	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
DEBIO 1143 effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines.
DEBIO 1143 effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors.

物理化学性质&存储条件

分子量	561.727
分子式	C32H43N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

参考文献

1. Cai Q, et al. J Med Chem. 2011 Apr 28;54(8):2714-26.

2. Langdon CG, et al. Oncotarget. 2015 Nov 10;6(35):37410-25.

3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.

4. Thibault B, et al. Sci Rep. 2018 Dec 14;8(1):17862.

DEBIO 1143 (Xevinapant;AT-406;DEBIO1143;SM406;ARRY-334543;D1143)

生物&药学活性

物理化学性质&存储条件

参考文献

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DEBIO 1143 (Xevinapant;AT-406;DEBIO1143;SM406;ARRY-334543;D1143)

生物&药学活性

物理化学性质&存储条件

参考文献

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