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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-DC-260126
DC-260126

Chemical Structure : DC-260126

CAS No.: 346692-04-4

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DC-260126 (DC260126)

货号: PC-70042Not For Human Use, Lab Use Only.

DC-260126 is a potent GPR40 agonist with IC50 of 6.28 uM for inhibition of Ca2+ stimulated by linoleic acid.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DC-260126 is a potent GPR40 agonist with IC50 of 6.28 uM for inhibition of Ca2+ stimulated by linoleic acid.
DC-260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells.
DC-260126 improves insulin tolerance but not glucose tolerance in obese Zucker rats.

物理化学性质&存储条件

分子量 307.383
分子式 C16H18FNO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-butylphenyl)-4-fluorobenzenesulfonamide

参考文献

1. Sun P, et al. PLoS One. 2013 Jun 11;8(6):e66744.

2. Zhang X, et al. Biomed Pharmacother. 2010 Nov;64(9):647-51.

3. Hu H, et al. Biochem Biophys Res Commun. 2009 Dec 18;390(3):557-63.

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