Centrinone-B |CAS:1798871-31-4 Probechem Biochemicals

Chemical Structure : Centrinone-B

CAS No.: 1798871-31-4

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Centrinone-B (Centrinone B;LCR-323)

货号: PC-45524Not For Human Use, Lab Use Only.

Centrinone-B (LCR-323) is a selective, reversible PLK4 inhibitor with Ki of 0.6 nM in vitro.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

Centrinone-B (LCR-323) is a selective, reversible PLK4 inhibitor with Ki of 0.6 nM in vitro.
Centrinone-B (LCR-323) causes centrosome depletion at 500 nM in human and other vertebrate cells.
Centrinone-B (LCR-323) shows >2000-fold selectivity over Aurora A and Aurara B.
Centrinone-B (LCR-323) leads to irreversible, p53-dependent G1 arrest by an unknown mechanism.

物理化学性质&存储条件

分子量	631.674
分子式	C27H27F2N7O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 8.5 mg/mL
Chemical Name/SMILES	4-Pyrimidinamine, 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-

参考文献

1. Wong YL, et al. Science. 2015 Jun 5;348(6239):1155-60.

2. Meitinger F, et al. J Cell Biol. 2016 Jul 18;214(2):155-66.

3. Guizzunti G, et al. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6590-E6599.

Centrinone-B (Centrinone B;LCR-323)

生物&药学活性

物理化学性质&存储条件

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Centrinone-B (Centrinone B;LCR-323)

生物&药学活性

物理化学性质&存储条件

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