CM-1758 | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : CM-1758

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CM-1758 (CM1758)

货号: PC-21607Not For Human Use, Lab Use Only.

CM-1758 is a novel histone deacetylase (HDAC) inhibitor with IC50 of 5 nM and 126 nM for HDAC1 and HDAC6, respectively.

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生物&药学活性

CM-1758 is a novel histone deacetylase (HDAC) inhibitor with IC50 of 5 nM and 126 nM for HDAC1 and HDAC6, respectively.
CM-1758 displays cytotoxic/cytostatic effects in bladder cancer cells with ow micromolar range (IC50=0.33-4.8 uM).
CM-1758 induces profound changes in the transcriptomic profile of BC cells, affecting pathways related to tumor cell aggressiveness and epigenetic machinery.
CM-1758 treatment affects histone acetylation, but also other epigenetic mechanisms, such as DNA methylation indirectly.
Anti-PD-L1 alone or in combination with CM-1758 reprogramed macrophage differentiation towards a M1-like polarization state and increased of pro-inflammatory cytokines systemically, yielding potential further antitumor effects.

物理化学性质&存储条件

分子量	532.60
分子式	C28H32N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4-[[[2-(2,5-dimethyl-3-furyl)-6,7-dimethoxy-4-quinolyl]amino]methyl]-1-piperidyl]pyrimidine-5-carbohydroxamic Acid

参考文献

1. Rabal O, et al. J Med Chem. 2021;64:3392–426.

2. Nunes SP, et al. Cell Death Discov. 2024 Jan 4;10(1):1.

CM-1758 (CM1758)

生物&药学活性

物理化学性质&存储条件

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CM-1758 (CM1758)

生物&药学活性

物理化学性质&存储条件

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