CCT-244747 |CAS:1404095-34-6 Probechem Biochemicals

Chemical Structure : CCT-244747

CAS No.: 1404095-34-6

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CCT-244747 (CCT 244747;CCT244747)

货号: PC-45429Not For Human Use, Lab Use Only.

CCT-244747 (CCT244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM.

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5 mg	￥1200	In stock
10 mg	￥1920	In stock
25 mg	￥3600	In stock
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生物&药学活性

CCT-244747 (CCT244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM.
CCT-244747 displays 75-fold selectivity against FLT3 and >1,000-fold selectivity against CHK2 and CDK1.
CCT-244747 inhibits cellular CHK1 activity (IC50=29-170nM), significantly enhances the cytotoxicity of several anticancer drugs and abrogates drug-induced S and G2 arrest in multiple tumor cell lines.
CCT-244747 enhances antitumor activity of gemcitabine and irinotecan in vivo.

物理化学性质&存储条件

分子量	408.457
分子式	C20H24N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-

参考文献

1. Walton MI, et al. Clin Cancer Res. 2012 Oct 15;18(20):5650-61.

2. Lainchbury M, et al. J Med Chem. 2012 Nov 26;55(22):10229-40.

3. Barker HE, et al. Mol Cancer Ther. 2016 Sep;15(9):2042-54.

CCT-244747 (CCT 244747;CCT244747)

生物&药学活性

物理化学性质&存储条件

参考文献

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CCT-244747 (CCT 244747;CCT244747)

生物&药学活性

物理化学性质&存储条件

参考文献

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