CC-223 |CAS:1228013-30-6 Probechem Biochemicals

Chemical Structure : CC-223

CAS No.: 1228013-30-6

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CC-223 (CC223)

货号: PC-45098Not For Human Use, Lab Use Only.

CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase with IC50 of 16 nM.

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
100 mg	￥6580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase with IC50 of 16 nM.
CC-223 displays >200-fold selectivity over the related PI3K-α (IC50=4.0 uM), shows no significant inhibition of ATR or SMG1 and weakly inhibits DNA-PK (IC50=0.84 uM).
CC-223 inhibits mTORC1 (pS6RP and p4EBP1) and mTORC2 [pAKT(S473)] in cellular systems, exhibits growth inhibitory activity in hematologic and solid tumor cell lines.
CC-223 demonstrates tumor growth inhibition in multiple solid tumor xenografts.

物理化学性质&存储条件

分子量	397.4708
分子式	C21H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	Pyrazino[2,3-b]pyrazin-2(1H)-one, 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-

参考文献

1. Mortensen DS, et al. J Med Chem. 2015 Jul 9;58(13):5323-33.

2. Mortensen DS, et al. Mol Cancer Ther. 2015 Jun;14(6):1295-305.

3. Bendell JC, et al. Cancer. 2015 Oct 1;121(19):3481-90.

CC-223 (CC223)

生物&药学活性

物理化学性质&存储条件

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CC-223 (CC223)

生物&药学活性

物理化学性质&存储条件

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