CASK inhibitor 18

Chemical Structure : CASK inhibitor 18

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货号: PC-72703Not For Human Use, Lab Use Only.

CASK chemical probe 18 is a highly potent and selective CASK inhibitor with IC50 of 22 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CASK chemical probe 18 is a highly potent and selective CASK inhibitor with IC50 of 22 nM.
CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) is a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kinases with roles implicated in neuronal synapses and trafficking.
CASK chemical probe 18 is a first chemical probe for studying the biological roles of CASK.

物理化学性质&存储条件

分子量	610.351
分子式	C24H30Br2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide

参考文献

1. Nadine Russ, et al. J Med Chem. 2021 Oct 14;64(19):14358-14376.