BRD-4770 |CAS:1374601-40-7 Probechem Biochemicals

Chemical Structure : BRD-4770

CAS No.: 1374601-40-7

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BRD-4770 (BRD 4770;BRD4770)

货号: PC-45050Not For Human Use, Lab Use Only.

A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3480	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

BRD-4770 is a SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells.
BRD-4770 decreases H3K9 trimethylation level in PANC-1 cells with EC50 of 5 uM.
BRD-4770 induces senescence, and inhibits both anchorage-dependent and -independent proliferation in PANC-1 cells.
BRD-4770 also increases LC3-II levels and the autophagosome number in PANC-1 cells combined with Gossypol.

物理化学性质&存储条件

分子量	413.4684
分子式	C25H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester

参考文献

1. Yuan Y, et al. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.

2. Yuan Y, et al. Cell Death Dis. 2013 Jun 27;4:e690.

3. Zhang X, et al. Toxicol Appl Pharmacol. 2016 Aug 1;304:42-7.

BRD-4770 (BRD 4770;BRD4770)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BRD-4770 (BRD 4770;BRD4770)

生物&药学活性

物理化学性质&存储条件

参考文献

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