BI 1467335 (PXS-4728A) | VAP-1 inhibitor | Probechem Biochemicals

Chemical Structure : BI 1467335

CAS No.: 1478364-68-9

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BI 1467335 (PXS-4728A, PXS4728)

货号: PC-61473Not For Human Use, Lab Use Only.

BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
BI 1467335 (PXS-4728A) displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases.
BI 1467335 (PXS-4728A) diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.

物理化学性质&存储条件

分子量	316.8
分子式	C15H21FN2O2.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride

参考文献

1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42.

2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175.

3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.

BI 1467335 (PXS-4728A, PXS4728)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI 1467335 (PXS-4728A, PXS4728)

生物&药学活性

物理化学性质&存储条件

参考文献

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